Understanding how HIV-infected cells persist and affect treatment outcomes
High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir
This study is looking at the hidden HIV-infected cells that make it hard to treat the virus and find a cure, especially in tough spots like the brain, and it invites patients to share samples and information to help us learn more about how these cells survive and how we might get rid of them.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11080763 on NIH RePORTER |
What this research studies
This research investigates the long-lived reservoirs of HIV-infected cells that complicate treatment and remission. It aims to identify the factors that contribute to the survival and proliferation of these cells, particularly in challenging areas like the central nervous system. By analyzing various clinical cohorts and employing innovative methodologies, the research seeks to uncover how these reservoirs behave and respond to potential eradication strategies. Patients may have the opportunity to contribute samples and data to help advance our understanding of HIV persistence.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals living with HIV who have undergone treatment interruption or are interested in contributing to research on HIV persistence.
Not a fit: Patients who are not living with HIV or those who have never received antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for achieving sustained HIV remission and potentially eradicating the virus.
How similar studies have performed: Previous research has shown promise in understanding HIV reservoirs, but this study aims to explore novel aspects of persistence and eradication strategies.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Li, Jonathan — Brigham and Women's Hospital
- Study coordinator: Li, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.