Understanding how HIV hides in the body during treatment
Single Cell Analysis of HIV-1 Latent reservoir establishment in Humanized Mice
This study is looking at how HIV hides in certain immune cells, making it tough to get rid of the virus even with treatment, and it aims to find new ways to target and eliminate these hidden cells to help people living with HIV.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10980503 on NIH RePORTER |
What this research studies
This research investigates how HIV can establish a latent reservoir in the body, making it difficult to eliminate the virus even with treatment. Using humanized mice, the study focuses on single-cell analysis to understand the mechanisms that allow HIV to remain undetected in certain immune cells, particularly CD4+ T cells. By examining the early stages of infection and the cellular pathways involved, the research aims to uncover why some cells become reservoirs for the virus. This could lead to new strategies for targeting and eliminating these hidden HIV-infected cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are undergoing antiretroviral therapy and have not achieved a complete cure.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS with significant immune system damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in curing HIV by identifying ways to eliminate latent reservoirs of the virus.
How similar studies have performed: Other research has shown promise in understanding HIV latency, but this specific approach using single-cell analysis in humanized mice is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Doanman, Donald — Icahn School of Medicine at Mount Sinai
- Study coordinator: Doanman, Donald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.