Understanding how HIV hides in the body and how to reactivate it
Novel single genome approaches to determine the mechanisms of HIV latent infection in blood, gut, and lymph nodes
This study is looking at how HIV hides in the body and what might wake it up, using samples from people on treatment, to help find better ways to get rid of the virus for good.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10611415 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind HIV's latent infection in various parts of the body, including blood and gut tissues. By using a novel transcription profiling approach, researchers aim to identify how HIV remains dormant and what factors can trigger its reactivation. The study focuses on analyzing cells from patients who are on antiretroviral therapy to better understand the barriers to HIV eradication. This knowledge could lead to the development of more effective treatments for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy.
Not a fit: Patients who are not infected with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in HIV treatment, potentially allowing for a functional cure.
How similar studies have performed: Other research has shown promise in understanding HIV latency, but this approach is innovative and aims to provide new insights.
Where this research is happening
San Francisco, United States
- Northern California Institute/res/edu — San Francisco, United States (Active)
Researchers
- Principal investigator: Yukl, Steven a — Northern California Institute/res/edu
- Study coordinator: Yukl, Steven a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.