Understanding how HIV hides in the body and how to activate it for treatment.
Integrative Single-Cell Analysis of Transcriptome, Epigenome, and Lineage in HIV Latency and Activation
This study is looking at how some cells with HIV can stay hidden and avoid treatment, and it's for people living with HIV who want to understand how researchers are trying to find new ways to wake up and eliminate these hidden virus reservoirs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10747889 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind HIV latency, focusing on how certain cells can remain dormant and evade treatment. By analyzing single cells, the team aims to identify specific markers and biochemical factors that control when these latent cells become active. The approach combines advanced sequencing techniques with computational methods to explore the relationship between a cell's genetic and epigenetic state and its ability to harbor the virus. This could lead to new strategies for targeting and eliminating the viral reservoir in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have been on antiretroviral therapy and have a history of viral latency.
Not a fit: Patients who are newly diagnosed with HIV or those who do not have a history of viral latency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that completely eliminate HIV from the body.
How similar studies have performed: Previous research has shown promise in targeting latent HIV reservoirs, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Collins, Kathleen L. — University of Michigan at Ann Arbor
- Study coordinator: Collins, Kathleen L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.