Understanding how HIV hides in the body and finding ways to eliminate it
Official title: Modeling the HIV latent reservoir, latency reversal and immunotherapeutics for HIV cure
Funded at Triad National Security, LLC · NIH-10867468 · Data updated 2026-11-12
This study is looking into why some people with HIV can keep the virus under control without ongoing treatment while others can't, and it's for anyone living with HIV who wants to understand more about how their body interacts with the virus and what new ways might help lead to a cure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Triad National Security, LLC NIH-funded |
| Lab location | 1 site (Los Alamos, UNITED STATES) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $589,470 |
| NIH project number | 5R01AI152703-05 |
| Project ID | NIH-10867468 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who have been on antiretroviral therapy and are interested in potential curative approaches.
✕Less likely to help
Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates the hidden reservoir of HIV-infected cells that remain in patients even after effective treatment. It aims to understand why some individuals can control the virus without ongoing therapy, while others cannot. By creating a mathematical model that incorporates recent biological findings, the researchers will analyze the complex interactions between the immune system and these latent cells. This approach seeks to identify new strategies for achieving a functional or complete cure for HIV.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eliminate HIV from the body, offering a potential cure for patients.
How similar studies have gone: Previous research has shown promise in understanding HIV dynamics and has led to advancements in treatment strategies, indicating that this approach could build on existing knowledge.
Where this research is happening
-
Triad National Security, LLC
Los Alamos, United States Active
Researchers
- Principal investigator: Ke, Ruian — Triad National Security, LLC
- Study coordinator: Ke, Ruian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.