Understanding how HIV hides in resting immune cells
Establishing HIV-1 chromatin in resting T cells: Vpr, latency, and H2A.Z
This study is looking at how HIV hides in certain immune cells and how we might be able to wake it up with specific drugs, which could help us find better ways to get rid of the virus for good.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10558472 on NIH RePORTER |
What this research studies
This research investigates how HIV-1 establishes latency in resting CD4 T cells, which is a significant barrier to curing HIV. It focuses on the role of chromatin modifications and the viral protein Vpr in regulating HIV expression. By studying the installation of nucleosomes around the viral DNA, the research aims to identify how certain drugs can reactivate latent HIV. This could lead to better therapeutic strategies to eliminate the virus from the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have a latent infection and are currently on antiretroviral therapy.
Not a fit: Patients who are newly diagnosed with HIV or those who do not have a latent infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reactivate and eliminate latent HIV from the body.
How similar studies have performed: Previous research has shown promising results in understanding HIV latency and chromatin modifications, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Levy, David N — New York University
- Study coordinator: Levy, David N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.