Understanding how HIV hides in immune cells
Official title: Determinants of HIV latency in CD4+ T lymphocytes
Funded at Icahn School of Medicine at Mount Sinai · NIH-11011294 · Data updated 2026-11-12
This study is looking at how HIV hides in certain immune cells, called CD4+ T lymphocytes, to better understand how it stays in the body and to find new ways to help get rid of it for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $818,975 |
| NIH project number | 5R01AI179598-02 |
| Project ID | NIH-11011294 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who have a detectable viral load and are on antiretroviral therapy.
✕Less likely to help
Patients who are HIV-negative or those with acute HIV infections may not benefit from this research.
What this research studies
This research investigates the mechanisms behind HIV latency in CD4+ T lymphocytes, which are crucial immune cells. By analyzing both productive and non-productive HIV infections in these cells, the study aims to uncover the dynamic nature of the HIV reservoir. The researchers will utilize advanced techniques, including transcriptome analysis and genome editing, to identify specific genetic markers and transcriptional programs associated with latent infections. This comprehensive approach could lead to new strategies for targeting and potentially eradicating HIV from the body.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in HIV treatment and possibly a cure by targeting latent HIV reservoirs.
How similar studies have gone: Previous research has shown promise in understanding HIV latency, but this approach aims to provide novel insights into the dynamic nature of the HIV reservoir.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Simon, Viviana a — Icahn School of Medicine at Mount Sinai
- Study coordinator: Simon, Viviana a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.