Understanding how HIV hides and how to wake it up
Novel Epigenetic Marks for HIV Latency Entry and Reversal
This study is looking at how HIV can hide in the body and is exploring new ways to wake it up so it can be treated, which could help people living with HIV find better therapies in the future.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10885922 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that allow HIV to remain dormant in the body and explores new ways to activate the virus for treatment. By focusing on epigenetic changes, particularly the role of crotonylation, the study aims to identify how these modifications can influence HIV transcription and latency. The researchers will analyze the chromatin structure around the HIV promoter to develop strategies that could potentially eliminate hidden HIV reservoirs. Patients may benefit from insights that could lead to more effective therapies for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have developed latent infections and are seeking new treatment options.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in eradicating latent HIV reservoirs, improving treatment outcomes for patients living with HIV.
How similar studies have performed: Previous research has shown promise in targeting HIV latency through epigenetic modifications, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Jiang, Guochun — Univ of North Carolina Chapel Hill
- Study coordinator: Jiang, Guochun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.