Understanding how HIV hides and comes back
Administrative Core
A team at Northwestern is coordinating work to learn how HIV stays hidden in the body and why it can return, with the goal of helping people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11381207 on NIH RePORTER |
What this research studies
A program at Northwestern brings together multiple research projects that use advanced lab methods, animal models, and human samples to study HIV persistence and viral rebound. The Administrative Core keeps all projects coordinated, shares data and resources, tracks timelines and budgets, and supports communication among investigators and collaborators. The work includes laboratory techniques, nonhuman primate studies, and analysis of patient-derived samples to pinpoint where and how HIV persists. By linking these efforts, the program aims to speed discoveries that could guide future clinical approaches.
Who could benefit from this research
Good fit: People living with HIV—especially those on antiretroviral therapy who can provide blood or tissue samples or join related clinical projects—would be the appropriate candidates for related studies.
Not a fit: People without HIV or those not eligible or willing to participate in linked clinical or sample-donation efforts are unlikely to receive direct benefit from this program.
Why it matters
Potential benefit: If successful, this work could point to ways to eliminate hidden HIV reservoirs or prevent the virus from returning after stopping treatment.
How similar studies have performed: Previous research has identified some HIV reservoirs and methods to delay rebound but a proven cure remains elusive, so this program builds on promising but still exploratory work.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Hope, Thomas — Northwestern University
- Study coordinator: Hope, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.