Understanding how HIV evolves to escape the immune system
Defining HIV evolution at the innate immune interface
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10948374
This study is looking at how HIV can quickly change to avoid being attacked by the immune system, focusing on a part of the virus called the capsid, and it aims to find ways to create better treatments that keep the virus from escaping our defenses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10948374 on ClinicalTrials.gov |
What this research studies
This research investigates how HIV can rapidly change and evade the body's immune defenses, particularly focusing on the viral capsid, which is a key target for immune response. By using advanced techniques to introduce mutations in the HIV virus, the researchers aim to identify which changes allow the virus to escape from the immune system and which are detrimental to its survival. This comprehensive analysis will help in designing new therapies that can effectively target the virus while preventing it from developing resistance. Patients may benefit from insights that could lead to more effective treatments for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing challenges with current antiviral therapies.
Not a fit: Patients who are not infected with HIV or those who have already achieved viral suppression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of innovative therapies that better control HIV and reduce its ability to mutate and evade treatment.
How similar studies have performed: Previous research has shown promise in understanding viral evolution and immune interactions, but this specific approach using high throughput mutagenesis is relatively novel.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TENTHOREY, JEANNETTE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: TENTHOREY, JEANNETTE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus