Understanding how HIV enters cells
Structure-function studies of the membrane-interacting domains of HIV-1 Env spike
This project aims to understand how the HIV virus enters human cells, which is a key step for developing new vaccines and treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11094922 on NIH RePORTER |
What this research studies
To infect cells, viruses like HIV must first merge with the cell's outer layer. This process relies on special viral proteins that change shape to allow the virus to enter. We are studying the parts of the HIV protein that interact with the cell membrane, as these are crucial for infection and are important targets for new medicines. By understanding these structures, we hope to find new ways to block HIV from entering cells.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals living with or at risk of HIV infection in the future.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: Success in this work could lead to the development of more effective vaccines and antiviral therapies to prevent or treat HIV infection.
How similar studies have performed: Previous research has identified some structures of viral fusion proteins, and the researchers have already made progress in determining structures of HIV-1 Env regions.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Bing — Boston Children's Hospital
- Study coordinator: Chen, Bing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.