Understanding how HIV controls its gene expression
Structural Biophysics of HIV Splicing and Transcriptional Control
This study is looking at how HIV controls its genes and how certain RNA structures help it do that, with the goal of finding new ways to treat HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10917782 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which HIV regulates its gene expression, focusing on the role of RNA structural dynamics in splicing and transcriptional control. By examining how specific RNA-protein complexes form and function, the study aims to identify new therapeutic targets to combat HIV. The researchers will explore the biophysical properties of RNA structures near HIV splice sites and their impact on viral replication. This innovative approach seeks to uncover the complexities of HIV's interaction with host cellular machinery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may benefit from novel therapeutic interventions.
Not a fit: Patients who are not infected with HIV or those who have already achieved viral suppression with current therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating HIV and reducing viral latency.
How similar studies have performed: Other research has shown promise in targeting RNA structures for therapeutic interventions in viral infections, indicating potential for success in this novel approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Tolbert, Blanton Smith — University of Pennsylvania
- Study coordinator: Tolbert, Blanton Smith
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.