Understanding How HIV Changes Shape
Conformational Landscape of the HIV-1 Envelope Glycoproteins
['FUNDING_R01'] · DANA-FARBER CANCER INST · NIH-11063294
This work explores how the outer shell of the HIV virus changes its shape to enter human cells, which is key to developing new treatments and vaccines.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DANA-FARBER CANCER INST (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11063294 on ClinicalTrials.gov |
What this research studies
The HIV virus has a special protein on its surface, called Env, that helps it get into our cells. This protein can change its shape, which is important for the virus to infect us and also helps it hide from our immune system. We are looking closely at these shape changes to understand how they work. By learning more about how Env changes, we hope to find new ways to stop the virus from entering cells.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future clinical applications would target individuals at risk for or living with HIV.
Not a fit: Patients not living with or at risk for HIV would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for designing more effective HIV vaccines and antiviral medications that block the virus from infecting cells.
How similar studies have performed: Understanding the HIV Env protein has been a long-standing area of research, with many studies contributing to our current knowledge, and this work builds upon those foundations.
Where this research is happening
BOSTON, UNITED STATES
- DANA-FARBER CANCER INST — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SODROSKI, JOSEPH G — DANA-FARBER CANCER INST
- Study coordinator: SODROSKI, JOSEPH G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus