Understanding how HIV behaves in the body to improve treatment options
Leaving, Coming, and Staying HIV Obligate Microenvironments (HOME)
This study is looking at how HIV hides in the body and what affects it, especially in people who have stopped their treatment, to help find better ways to manage the virus and possibly lead to a cure.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11076190 on NIH RePORTER |
What this research studies
This research investigates the complex dynamics of HIV reservoirs in the body, focusing on how viral, host, and environmental factors influence these reservoirs during and after antiretroviral therapy (ART). By utilizing advanced single-cell and single-genome technologies, the study aims to uncover the mechanisms that govern HIV behavior, particularly in patients who have stopped ART. The research involves collecting clinical data and biological samples from altruistic individuals with HIV, including those who have chosen to stop treatment, to gain insights into the virus's activity and potential vulnerabilities. This approach seeks to provide a more personalized understanding of HIV management and potential pathways to a cure.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who are willing to participate in advanced studies and may have stopped antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who are not interested in participating in research involving post-mortem sample collection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV treatments and potentially a cure by identifying new strategies to target HIV reservoirs.
How similar studies have performed: Previous research has shown promise in understanding HIV dynamics through innovative approaches, but this specific methodology is relatively novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Smith, David Mitchell — University of California, San Diego
- Study coordinator: Smith, David Mitchell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.