Understanding how HIV and tuberculosis interact in the body
Official title: HIV/Mycobacterium tuberculosis co-infection: cellular dynamics in granulomas
Funded at University of Pittsburgh at Pittsburgh · NIH-10837671 · Data updated 2026-11-12
This study is looking at how HIV and tuberculosis (TB) work together in the body, especially how the immune system responds and forms protective structures called granulomas, to better understand why people with HIV are more likely to get TB.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 1F31AI181616-01 |
| Project ID | NIH-10837671 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are at risk of developing tuberculosis.
✕Less likely to help
Patients who do not have HIV or tuberculosis may not receive any benefit from this research.
What this research studies
This research investigates the complex interactions between HIV and Mycobacterium tuberculosis (Mtb) co-infection, focusing on the immune response and the formation of granulomas, which are structures that help contain the bacteria. By examining how these granulomas function and their spatial architecture, the study aims to uncover the underlying mechanisms that contribute to the increased risk of tuberculosis in individuals living with HIV. The research employs advanced cellular and immunological techniques to analyze the dynamics of immune cells in response to these infections.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating tuberculosis in patients co-infected with HIV.
How similar studies have gone: Previous research has shown that understanding the immune response in co-infections can lead to significant advancements in treatment strategies, indicating potential for success in this area.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Medrano, Jessica Marie — University of Pittsburgh at Pittsburgh
- Study coordinator: Medrano, Jessica Marie
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-
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-
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-
Air pollution and TB transmission in Kampala’s urban slums
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.