Understanding how HIV and other infections affect vaccine responses in young children
Official title: Identifying critical determinants of vaccine-induced cellular and humoral immunity from birth through childhood in HIV-exposed and unexposed children
Funded at University of Washington · NIH-10989934 · Data updated 2026-11-12
This study looks at how being exposed to infections like HIV and cytomegalovirus early in life affects how well children respond to vaccines, helping us understand what might make vaccines less effective for both HIV-exposed and unexposed kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | November 20, 2023 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $577,777 |
| NIH project number | 5R01AI181634-02 |
| Project ID | NIH-10989934 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years, particularly those who are HIV-exposed or unexposed.
✕Less likely to help
Patients who are older than 11 years or those who do not have any exposure to HIV or CMV may not benefit from this research.
What this research studies
This research investigates how early-life exposure to infections like HIV and cytomegalovirus (CMV) influences the immune responses to vaccines in children from birth through childhood. By examining both humoral (antibody) and cellular immune responses, the study aims to identify critical factors that may impair vaccine efficacy in HIV-exposed and unexposed children. The research will involve monitoring immune responses in children over time to better understand the impact of these infections on their ability to respond to vaccinations effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies that enhance immune responses in vulnerable children, ultimately reducing preventable deaths.
How similar studies have gone: Previous studies have shown that HIV exposure can negatively impact vaccine responses, but this research aims to explore this area further, particularly regarding cellular responses, making it a novel investigation.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Slyker, Jennifer Ann — University of Washington
- Study coordinator: Slyker, Jennifer Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.