Understanding how HIV and opioids affect brain inflammation and damage
Disentangling the HIV/opioid intertwined mechanisms on mitochondrial mediated inflammasome activation, neurotoxicity and targeting strategies: In vivo and in vitro analyses of fresh human brain
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11055845
This study is looking at how HIV and opioid use affect brain inflammation and damage, with the hope of finding ways to help improve thinking and memory for people dealing with these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11055845 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between HIV and opioid use on brain inflammation and neurotoxicity. By analyzing fresh human brain specimens, the team aims to understand how HIV proteins activate inflammatory pathways and how opioids may exacerbate these effects. The study employs advanced methodologies, including neuropathology and cellular analyses, to uncover the mechanisms behind cognitive impairment associated with these conditions. The goal is to identify potential targeted interventions that could improve cognitive function in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV, particularly those experiencing cognitive impairment, as well as individuals who use opioids.
Not a fit: Patients who do not have HIV or opioid use may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that mitigate cognitive impairment in individuals living with HIV and those who use opioids.
How similar studies have performed: While the individual effects of HIV and opioids on brain health have been studied, this research aims to explore their combined impact, making it a novel approach in this area.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAILLON, ANTOINE — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: CHAILLON, ANTOINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus