Understanding how HIV and opioid use affect the brain
Uncovering HIV/opioid effects in the brain at the single cell level: transcription, chromatin accessibility, and reservoir analysis in the SIV/cART/morphine/rhesus monkey model
['FUNDING_U01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-11126675
This project aims to understand how HIV and opioid use together change brain cells, using advanced techniques in a non-human primate model.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-11126675 on ClinicalTrials.gov |
What this research studies
We want to learn how HIV and opioid use impact the brain at a very detailed level, looking at individual brain cells. By studying a model that closely mimics human conditions, we can see how the virus and drugs affect different types of brain cells and how genes are turned on or off. This helps us understand the complex changes that happen in the brain when someone has HIV and uses opioids. We are also looking for hidden virus in the brain, which is important for finding new ways to treat HIV.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals living with HIV who also use opioids by providing insights into their brain health.
Not a fit: Patients not living with HIV or not affected by opioid use may not directly benefit from this specific line of research.
Why it matters
Potential benefit: This work could lead to a better understanding of how HIV and opioid use harm the brain, potentially guiding the development of new treatments to protect brain health.
How similar studies have performed: This project uses advanced single-cell technologies, building on existing knowledge of HIV and opioid effects, but applies these techniques in a novel, comprehensive way to understand their combined impact.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FOX, HOWARD S — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: FOX, HOWARD S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus