Understanding how HIV and HPV infections affect oropharyngeal cancer development
Dissecting Tumor-Immune Interactions in HIV-HPV Co-Infection-Associated Oropharyngeal Cancer using Single Cell Sequencing and Novel Mouse Models
This study is looking at how HIV affects the immune system in people with HPV-related throat cancer, hoping to find new ways to help patients fight the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11093567 on NIH RePORTER |
What this research studies
This research investigates the interactions between HIV and HPV infections in the development of oropharyngeal squamous cell carcinoma (OPSCC). By utilizing advanced single-cell sequencing techniques and novel mouse models, the study aims to explore how HIV influences the immune response, particularly focusing on CD8+ T cells, in the context of HPV-positive OPSCC. The research will analyze the immune cell landscape and the exhaustion of tumor-infiltrating lymphocytes, which could lead to new insights into prevention and treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with oropharyngeal squamous cell carcinoma who are also living with HIV.
Not a fit: Patients who do not have oropharyngeal cancer or are not infected with HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention, diagnosis, and treatment strategies for patients with oropharyngeal cancer associated with HIV and HPV.
How similar studies have performed: Previous research has shown promising results in understanding tumor-immune interactions in cancer, but this specific investigation into HIV-HPV co-infection in OPSCC is relatively novel.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Yin, Shanye — Albert Einstein College of Medicine
- Study coordinator: Yin, Shanye
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.