Understanding how HIV and cocaine affect brain inflammation and nerve cell function
Mechanisms underlying dysregulated neuroimmune signaling and neuronal dysfunction in HIV (+) individuals with cART and cocaine
This study looks at how HIV, cocaine use, and HIV medications affect brain health, especially how they can cause inflammation and harm to nerve cells, with the goal of finding better ways to help people dealing with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10458061 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between HIV infection, cocaine abuse, and the effects of antiretroviral therapy on brain health. It focuses on how these factors contribute to neuroinflammation and damage to nerve cells, which are critical for proper brain function. By examining the molecular pathways involved, the study aims to uncover the mechanisms that lead to these harmful effects, potentially leading to improved treatment strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are undergoing combination antiretroviral therapy and have a history of cocaine use.
Not a fit: Patients who do not have HIV or a history of cocaine use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better therapeutic approaches for managing neuroinflammation and neuronal dysfunction in individuals living with HIV who also struggle with cocaine abuse.
How similar studies have performed: Other research has shown promising results in understanding neuroinflammation in HIV, but the specific interactions with cocaine and antiretroviral therapy are still being explored, making this a novel investigation.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Buch, Shilpa J. — University of Nebraska Medical Center
- Study coordinator: Buch, Shilpa J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.