Understanding how HIV and cocaine affect brain inflammation
Molecular mechanisms underlying HIV & Cocaine-mediated microglial activation: Targeting NLRP3 inflammasome
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-10665604
This study is looking at how HIV and cocaine affect brain inflammation and could lead to thinking problems, with the hope of finding new ways to help people with HIV improve their brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-10665604 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of HIV and cocaine on brain inflammation, particularly focusing on how these factors activate microglial cells, which are crucial for brain health. The study aims to explore the role of specific protein complexes called inflammasomes in this process, which may lead to neurocognitive disorders in individuals with HIV. By examining the interactions between HIV proteins and cocaine, the research seeks to uncover new therapeutic targets that could mitigate the harmful effects of these substances on the brain. Patients may benefit from insights that could lead to improved treatments for HIV-associated neurocognitive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of cocaine use and are experiencing cognitive impairments.
Not a fit: Patients who do not have HIV or a history of cocaine use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for individuals living with HIV and substance abuse issues.
How similar studies have performed: Previous research has shown that targeting inflammasomes can be effective in treating neuroinflammatory conditions, suggesting potential success for this approach.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUCH, SHILPA J. — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: BUCH, SHILPA J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.