Understanding how HIV affects walking and balance in older adults
Official title: Central Control and Neuroinflammatory Mechanisms of Locomotion in Older Adults with HIV
Funded at Albert Einstein College of Medicine · NIH-10990499 · Data updated 2026-11-12
This study is looking at how HIV affects walking and balance in older adults aged 50 and up, and it aims to find ways to help improve their mobility and reduce the risk of falls.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $721,743 |
| NIH project number | 5R01NS127697-03 |
| Project ID | NIH-10990499 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 50 and above who are living with HIV.
✕Less likely to help
Patients under the age of 50 or those without HIV may not benefit from this research.
What this research studies
This research investigates the impact of HIV on mobility and gait disorders in older adults, particularly those aged 50 and above. It focuses on how neuroinflammation and disruptions in brain circuitry may contribute to these mobility impairments. By using advanced imaging techniques and a dual-task walking paradigm, the study aims to assess brain activation during walking and identify potential interventions to improve walking performance and reduce fall risk. Participants will include older adults with HIV and a control group without HIV.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing mobility and reducing fall risk in older adults living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding mobility impairments in older adults, but this specific focus on HIV-related neuroinflammation is relatively novel.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Holtzer, Roee — Albert Einstein College of Medicine
- Study coordinator: Holtzer, Roee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.