Understanding how HIV affects the immune response to tuberculosis in children
Innate immune response of LTBI+HIV+ children
This study is looking at how the immune systems of children who have both HIV and a hidden tuberculosis infection work, so we can find out which kids are more likely to get sick with active tuberculosis and help them get the right care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11142177 on NIH RePORTER |
What this research studies
This research investigates the immune responses of children who are both HIV-positive and have latent tuberculosis infection (LTBI). It aims to identify the specific immune deficiencies that increase the risk of developing active tuberculosis in these children. By analyzing blood samples and immune cell responses, the study seeks to determine which children are at the highest risk for TB, allowing for targeted treatment and prevention strategies. The findings could lead to improved therapies for those most vulnerable to TB.
Who could benefit from this research
Good fit: Ideal candidates for this research are children who are HIV-positive and have been diagnosed with latent tuberculosis infection.
Not a fit: Patients who are not HIV-positive or do not have latent tuberculosis infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for children at high risk of developing tuberculosis due to their HIV status.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to tuberculosis, particularly in populations with HIV, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Vankayalapati, Ramakrishna — Saint Louis University
- Study coordinator: Vankayalapati, Ramakrishna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.