Understanding how HIV affects the immune response to hepatitis B
Official title: The role of neutralizing antibodies in natural and treatment-induced control of hepatitis B with and without HIV-1 co-infection
Funded at Johns Hopkins University · NIH-11004386 · Data updated 2026-11-12
This study is looking at how certain antibodies help fight hepatitis B in people who also have HIV, by examining blood samples from 185 participants to see how well their immune systems respond and how HIV might affect that response.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 24, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $368,297 |
| NIH project number | 5R01AI172546-03 |
| Project ID | NIH-11004386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are either co-infected with HIV and hepatitis B or have experienced acute hepatitis B.
✕Less likely to help
Patients who do not have hepatitis B or HIV, or those under 21 years old, may not benefit from this research.
What this research studies
This research investigates the role of neutralizing antibodies in the immune response to hepatitis B, particularly in individuals co-infected with HIV. It will analyze blood samples from 185 participants, including those with acute hepatitis B and varying outcomes, to assess the strength and durability of antibody responses. The study aims to determine how HIV influences these immune responses and the potential for reactivation of hepatitis B in affected individuals. By isolating specific B cells, the research seeks to deepen our understanding of the immune mechanisms at play.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for hepatitis B, especially in patients co-infected with HIV.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in co-infected individuals, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Bailey, Justin Richard — Johns Hopkins University
- Study coordinator: Bailey, Justin Richard
Related research
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-
HBV safety with long-acting HIV therapy for people with HIV
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.