Understanding how HIV affects the immune response to hepatitis B
The role of neutralizing antibodies in natural and treatment-induced control of hepatitis B with and without HIV-1 co-infection
This study is looking at how certain antibodies help fight hepatitis B in people who also have HIV, by examining blood samples from 185 participants to see how well their immune systems respond and how HIV might affect that response.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11004386 on NIH RePORTER |
What this research studies
This research investigates the role of neutralizing antibodies in the immune response to hepatitis B, particularly in individuals co-infected with HIV. It will analyze blood samples from 185 participants, including those with acute hepatitis B and varying outcomes, to assess the strength and durability of antibody responses. The study aims to determine how HIV influences these immune responses and the potential for reactivation of hepatitis B in affected individuals. By isolating specific B cells, the research seeks to deepen our understanding of the immune mechanisms at play.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are either co-infected with HIV and hepatitis B or have experienced acute hepatitis B.
Not a fit: Patients who do not have hepatitis B or HIV, or those under 21 years old, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for hepatitis B, especially in patients co-infected with HIV.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in co-infected individuals, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Bailey, Justin Richard — Johns Hopkins University
- Study coordinator: Bailey, Justin Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.