Understanding how HIV affects the immune response to hepatitis B
Neutralizing antibody responses during natural control of acute hepatitis B with and without HIV-1 coinfection
This study is looking at how HIV affects the immune system's response to hepatitis B in men who have had the virus, to better understand why people with HIV might be more likely to have problems with hepatitis B later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10891573 on NIH RePORTER |
What this research studies
This research investigates how HIV influences the body's immune response to hepatitis B, particularly focusing on the production of neutralizing antibodies and the characteristics of B cells involved in this response. The study will involve 185 men, including those with HIV, who have experienced acute hepatitis B, and will track their immune responses over a 30-month period. By comparing those who recover naturally from the infection to those who develop chronic hepatitis B, the research aims to uncover important differences in immune function. This could help identify why individuals with HIV are at a higher risk for hepatitis B reactivation.
Who could benefit from this research
Good fit: Ideal candidates for this research are men aged 21 and older who have experienced acute hepatitis B, particularly those with or without HIV.
Not a fit: Patients who do not have hepatitis B or are not infected with HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for individuals co-infected with HIV and hepatitis B.
How similar studies have performed: Previous research has shown varying immune responses in co-infected individuals, but this specific approach to studying neutralizing antibodies in the context of acute hepatitis B and HIV is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Bailey, Justin Richard — Johns Hopkins University
- Study coordinator: Bailey, Justin Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.