Understanding how HIV affects the gut's ability to heal itself
Modeling intestinal dysfunction in HIV infection with organoid technology
This study is looking at how HIV affects the ability of intestinal stem cells to heal and keep the gut healthy, using special lab-grown models to see how HIV interacts with these cells and what that means for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10762469 on NIH RePORTER |
What this research studies
This research investigates the impact of HIV infection on the regenerative capacity of intestinal stem cells, which are crucial for maintaining the gut's barrier function. By using organoid technology, researchers will create three-dimensional models of intestinal cells to study how HIV disrupts their normal function. The study will involve co-culturing these organoids with T cells to observe the interactions and effects of HIV on stem cell behavior. This approach aims to uncover the molecular mechanisms behind gut dysfunction in HIV-infected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing gastrointestinal issues.
Not a fit: Patients who are not infected with HIV or do not have gastrointestinal complications related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to restore gut health in people living with HIV.
How similar studies have performed: Previous research has shown promising results using organoid technology to study various gastrointestinal disorders, indicating potential for success in this novel application.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Ott, Melanie Maria — J. David Gladstone Institutes
- Study coordinator: Ott, Melanie Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.