Understanding how HIV affects T cell aging and mitochondrial function
HIV infection-induced mitochondrial dysfunction and premature T cell aging
['FUNDING_R15'] · EAST TENNESSEE STATE UNIVERSITY · NIH-10203459
This study is looking at how HIV affects the aging of certain immune cells called T cells, especially how it impacts their energy production, and it's for people living with controlled HIV who want to understand more about their health and potential new treatments.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EAST TENNESSEE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (JOHNSON CITY, UNITED STATES) |
| Trial ID | NIH-10203459 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of HIV infection on T cell aging, specifically focusing on mitochondrial dysfunction. The study aims to uncover the mechanisms that lead to impaired mitochondrial function in CD4 T cells from patients with controlled HIV. By analyzing mitochondrial DNA content and protein levels in these cells, researchers hope to identify potential targets for therapies that could restore T cell function and prevent depletion. The approach includes advanced techniques like Liquid Chromatography Mass Spectrometry to compare mitochondrial function in HIV-infected individuals and healthy subjects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have controlled viral loads.
Not a fit: Patients who are not living with HIV or those with advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve T cell function in HIV patients, enhancing their immune response.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial dysfunction in various conditions, suggesting that this approach could yield valuable insights in the context of HIV.
Where this research is happening
JOHNSON CITY, UNITED STATES
- EAST TENNESSEE STATE UNIVERSITY — JOHNSON CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAO, ZHI Q. — EAST TENNESSEE STATE UNIVERSITY
- Study coordinator: YAO, ZHI Q.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.