Understanding how HIV affects lung inflammation and COPD
Resetting the Clock in HIV associated COPD
['FUNDING_R01'] · FLORIDA INTERNATIONAL UNIVERSITY · NIH-10865095
This study is looking at how living with HIV might affect lung health, especially for those who smoke, by exploring how changes in our body's natural sleep-wake cycles can lead to lung inflammation, with the hope of finding new ways to help manage these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FLORIDA INTERNATIONAL UNIVERSITY (nih funded) |
| Locations | 1 site (MIAMI, UNITED STATES) |
| Trial ID | NIH-10865095 on ClinicalTrials.gov |
What this research studies
This research investigates the connection between HIV and chronic obstructive pulmonary disease (COPD) by focusing on how disruptions in the body's circadian rhythms may lead to increased lung inflammation. The study aims to identify specific gene expressions that are altered in individuals living with HIV, which could contribute to the development of COPD. By examining the role of a protein called SIRT1 and its relationship with other core clock genes, the research seeks to uncover the mechanisms behind lung issues in HIV patients, especially those who smoke. This could lead to new insights into managing and treating lung inflammation in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, particularly those who also have COPD or are at risk of developing it.
Not a fit: Patients who do not have HIV or related lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for lung inflammation and COPD in individuals living with HIV.
How similar studies have performed: While the specific approach of linking circadian rhythms to HIV-related lung issues is novel, there is existing research on the impact of circadian disruption on inflammation and lung diseases.
Where this research is happening
MIAMI, UNITED STATES
- FLORIDA INTERNATIONAL UNIVERSITY — MIAMI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UNWALLA, HOSHANG JEHANGIR — FLORIDA INTERNATIONAL UNIVERSITY
- Study coordinator: UNWALLA, HOSHANG JEHANGIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus