Understanding how HIV affects lung health in people with COPD
Official title: Aberrant Micro-managing of the Airway Epithelial Transcriptome in HIV-associated COPD
Funded at Florida International University · NIH-11015816 · Data updated 2026-11-12
This study is looking at how HIV can lead to lung problems like COPD, especially by exploring tiny molecules called microRNAs that affect how our genes work, and it aims to find ways to help improve lung health for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $639,342 |
| NIH project number | 5R01HL167655-03 |
| Project ID | NIH-11015816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who also have a diagnosis of chronic obstructive pulmonary disease.
✕Less likely to help
Patients who do not have HIV or COPD may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which HIV contributes to chronic obstructive pulmonary disease (COPD) in individuals living with HIV. It focuses on the role of microRNAs, which are small molecules that regulate gene expression, and how their dysregulation can lead to various lung issues. The study aims to identify specific signaling pathways affected by HIV and other factors like smoking, which may worsen lung health. By understanding these pathways, the research seeks to develop targeted interventions to improve lung function and overall health in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung health and quality of life for people living with HIV and COPD.
How similar studies have gone: Previous research has shown promising results in understanding the role of microRNAs in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Unwalla, Hoshang Jehangir — Florida International University
- Study coordinator: Unwalla, Hoshang Jehangir
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.