Understanding how HIV affects lung health and aging
Mechanisms of defective mitophagy and cellular senescence in HIV associated COPD
This study is looking at how lung problems, especially COPD, affect older people living with HIV, and it wants to understand how certain cell processes and smoking might be making their lungs worse, with the goal of finding new ways to help them breathe better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-10424538 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind lung diseases, particularly COPD, in aging individuals living with HIV. It focuses on how defective mitophagy and cellular senescence contribute to chronic inflammation and lung damage. The study examines the role of proinflammatory cytokines and the impact of nicotine addiction on lung health in HIV-infected populations. By exploring these pathways, the research aims to identify potential therapeutic targets for improving lung function in these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are aging individuals who are HIV-positive and have been diagnosed with COPD or other related lung diseases.
Not a fit: Patients who are not HIV-positive or do not have lung diseases such as COPD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung health and quality of life for individuals living with HIV.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can improve outcomes in chronic lung diseases, suggesting a promising avenue for this study.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Unwalla, Hoshang Jehangir — Florida International University
- Study coordinator: Unwalla, Hoshang Jehangir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.