Understanding how HIV affects lung disease in people from low and middle-income countries.
Official title: Harnessing multi-omics to identify host-microbiome interactions driving HIV-associated chronic obstructive pulmonary disease in low and middle income countries.
Funded at Duke University · NIH-10918374 · Data updated 2026-11-12
This study is looking at how HIV might increase the risk of lung problems, like COPD, in people living in low and middle-income countries, especially in sub-Saharan Africa, to help find better ways to spot and manage these issues for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 25, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $565,250 |
| NIH project number | 1DP1HL174240-01 |
| Project ID | NIH-10918374 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old living with HIV in low and middle-income countries.
✕Less likely to help
Patients who do not have HIV or are not at risk for COPD may not benefit from this research.
What this research studies
This research investigates the relationship between HIV and chronic obstructive pulmonary disease (COPD) in low and middle-income countries, particularly in sub-Saharan Africa. It aims to uncover the mechanisms that increase the risk of COPD in people living with HIV by examining the interactions between the host's immune system and the microbiome. By utilizing advanced multi-omics approaches, the study will analyze various biological markers and inflammatory pathways to identify those at the highest risk for developing COPD. This comprehensive understanding could lead to better identification and management of COPD in this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating COPD in individuals living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding the link between microbiome alterations and COPD, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Patel, Sweta Mahesh — Duke University
- Study coordinator: Patel, Sweta Mahesh
Related research
Other NIH-funded projects on the same topics.
-
Ethics-aware Multimodal AI for COPD prevention, diagnosis, and treatment
A broad AI model uses diverse health data to help predict and manage COPD in people, with an emphasis on ethics and fairness.
-
Positive airway pressure therapy for older veterans with COPD and sleep apnea overlap
A plan to see if using a CPAP/BAP therapy improves sleep, thinking, and quality of life for older veterans who have both COPD and sleep apnea.
-
Understanding how microbes and our bodies shape HIV-related COPD in LMICs
This project looks at how interactions between the human body and microbes may influence COPD in people living with HIV in low- and middle-income countries.
-
Anti-EMAP II antibody as a first-in-class treatment for COPD-related pulmonary hypertension
A first-in-class antibody treatment is being developed to help people with COPD-related pulmonary hypertension by blocking EMAP II, a molecule involved in lung injury and inflammation.
-
Non-coding RNA and COPD: how RNA structure changes with disease
A COPD research project explores how non-coding RNA structures in adults with COPD change due to genetic differences and how this affects gene activity.
-
ANT2 and mitochondrial dysfunction in COPD: how energy transport affects lung repair
This project studies how a key mitochondrial transporter (ANT2) may drive aging-like cell changes and repair problems in the lungs of people with COPD.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.