Understanding how HIV affects lung disease in people from low and middle-income countries.
Harnessing multi-omics to identify host-microbiome interactions driving HIV-associated chronic obstructive pulmonary disease in low and middle income countries.
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-10918374
This study is looking at how HIV might increase the risk of lung problems, like COPD, in people living in low and middle-income countries, especially in sub-Saharan Africa, to help find better ways to spot and manage these issues for those affected.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10918374 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between HIV and chronic obstructive pulmonary disease (COPD) in low and middle-income countries, particularly in sub-Saharan Africa. It aims to uncover the mechanisms that increase the risk of COPD in people living with HIV by examining the interactions between the host's immune system and the microbiome. By utilizing advanced multi-omics approaches, the study will analyze various biological markers and inflammatory pathways to identify those at the highest risk for developing COPD. This comprehensive understanding could lead to better identification and management of COPD in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old living with HIV in low and middle-income countries.
Not a fit: Patients who do not have HIV or are not at risk for COPD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating COPD in individuals living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding the link between microbiome alterations and COPD, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PATEL, SWETA MAHESH — DUKE UNIVERSITY
- Study coordinator: PATEL, SWETA MAHESH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus