Understanding how HIV affects lung blood vessels
Official title: Novel mechanisms of HIV-associated pulmonary vascular disease
Funded at Augusta University · NIH-11171664 · Data updated 2026-11-12
This study is looking at how HIV affects lung and heart health by examining how certain proteins from the virus change blood vessels in the lungs, especially as people get older, to help improve care for those living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | August 20, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $760,760 |
| NIH project number | 5R01HL176323-02 |
| Project ID | NIH-11171664 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV, particularly those experiencing cardiovascular issues or aging-related complications.
✕Less likely to help
Patients who are not living with HIV or do not have cardiovascular complications may not benefit from this research.
What this research studies
This research investigates the impact of HIV on pulmonary vascular disease (PVD), a serious complication affecting the lungs and heart in people living with HIV. The study aims to identify how certain proteins from the HIV virus contribute to changes in blood vessels in the lungs, particularly as individuals age. Using mouse models, researchers will explore the mechanisms behind these changes and how they relate to the overall health of the cardiovascular system. The findings could lead to new insights into managing heart and lung health in HIV patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for pulmonary vascular disease in individuals living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding HIV-related complications, but this specific approach to pulmonary vascular disease is relatively novel.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Belin de Chantemele, Eric J — Augusta University
- Study coordinator: Belin de Chantemele, Eric J
Related research
Other NIH-funded projects on the same topics.
-
Sub-second acetylcholine release in the brain for Alzheimer’s dementia
A small, quick stimulations-based study aims to boost a brain chemical called acetylcholine to help people with Alzheimer’s disease by using a targeted brain stimulation approach.
-
Cardiac polyploidy regulators in fruit flies and humans
A researcher is studying how heart cells in humans and fruit flies control their DNA content to grow, hoping to uncover genes that keep the heart healthy.
-
Georgia CaRes: Cancer Research and Care in Georgia
A Georgia-wide program helps adults with cancer take part in trials and cancer-control efforts across rural and urban communities.
-
ZBP1's role in how the body handles LPS and bacterial infection
This NIH grant looks at how ZBP1 helps cells respond to LPS and protect against bacterial infection, focusing on a new pathway that can trigger inflammation and cell death.
-
How the protein RHOE may control scarring in the heart after a heart attack
This work looks at whether increasing a protein called RHOE in heart fibroblasts can reduce harmful scarring after a heart attack.
-
Length of Bisphosphonate Use and Breaks: Guiding Safe, Long-Term Osteoporosis Care
A clinician-friendly tool helps older adults and their doctors decide how long to stay on bisphosphonates and whether a drug holiday makes sense.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.