Understanding how HIV affects kidney disease in patients with diabetes
Elucidating the Molecular Mechanisms that Mediate DKD Progression in Patients Living with HIV
This study is looking at how HIV can make kidney problems worse for people with diabetes, and it aims to find new ways to help those patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10982490 on NIH RePORTER |
What this research studies
This research investigates the relationship between HIV infection and the progression of diabetic kidney disease (DKD) in patients living with HIV. It aims to uncover the molecular mechanisms that contribute to DKD by using advanced techniques such as RNA sequencing in both mouse models and human patients. The study focuses on how chronic HIV infection, even in patients with low viral loads, can worsen kidney health, particularly in those with diabetes. By identifying these mechanisms, the research seeks to pave the way for new treatments and drug targets for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients living with HIV who also have diabetes or are at risk of developing diabetic kidney disease.
Not a fit: Patients without HIV or diabetes may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetic kidney disease in patients living with HIV.
How similar studies have performed: Previous studies have shown promising results in understanding the interplay between HIV and kidney disease, indicating that this research builds on established findings.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: He, John Cijiang — Icahn School of Medicine at Mount Sinai
- Study coordinator: He, John Cijiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.