Understanding how HIV affects inflammation and gene expression in the brain
Official title: Epigenetic profiling of HIV-associated neuroinflammation and proviral expression in the brain
Funded at University of California, San Diego · NIH-10924866 · Data updated 2026-11-12
This study is looking at how HIV affects the brain and can lead to memory and thinking problems, even when people are on treatment, by examining brain samples from those living with HIV to better understand what keeps the virus active and causes inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $818,886 |
| NIH project number | 1R01NS137852-01 |
| Project ID | NIH-10924866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who have experienced neurocognitive disorders.
✕Less likely to help
Patients who are not living with HIV or those who do not have any cognitive impairments related to HIV may not benefit from this research.
What this research studies
This research investigates the effects of HIV infection on neuroinflammation and gene expression in the brain. It focuses on understanding how HIV persists in brain cells despite antiretroviral therapy and how this persistence contributes to cognitive disorders. By analyzing brain tissue samples from individuals living with HIV, the study aims to identify the epigenetic factors that regulate HIV expression and inflammation. The research employs advanced single-cell sequencing techniques to gain insights into the cellular mechanisms involved.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to reduce neuroinflammation and improve cognitive function in individuals living with HIV.
How similar studies have gone: Other research has shown promising results in understanding neuroinflammation in HIV, but this specific approach using epigenetic profiling is relatively novel.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Lamere, Sarah Adrianne — University of California, San Diego
- Study coordinator: Lamere, Sarah Adrianne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.