Understanding how HIV affects children’s immune systems
Official title: Project-003
Funded at Emory University · NIH-11060886 · Data updated 2026-11-12
This study is looking at how the immune system works with HIV in children to understand why the virus can stay in their bodies, and it aims to find new ways to help kids with HIV get better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $348,091 |
| NIH project number | 5P01HD112217-03 |
| Project ID | NIH-11060886 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children living with HIV, particularly those in neonatal and childhood age groups.
✕Less likely to help
Patients who are adults or those without HIV may not receive any benefit from this research.
What this research studies
This research aims to explore the interactions between the immune system and HIV in children, focusing on how these interactions contribute to the persistence of HIV reservoirs in the body. By studying the unique immune environment of children living with HIV, the project seeks to identify specific metabolites and cytokines that influence the size and stability of HIV reservoirs. The research will involve quantifying the role of thymic output and the presence of HIV-infected cells in the immune response of children. Ultimately, the goal is to develop targeted strategies for curing HIV in pediatric populations.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatment strategies that effectively target and eliminate HIV reservoirs in children.
How similar studies have gone: Previous research has shown promise in understanding HIV persistence in adults, but this specific focus on children is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Sharma, Ashish Arunkumar — Emory University
- Study coordinator: Sharma, Ashish Arunkumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.