Understanding how HIV affects children's immune systems
Official title: Project-002
Funded at Emory University · NIH-11060884 · Data updated 2026-11-12
This study is looking at how HIV affects the immune systems of children and how certain immune cells help control the virus, with the goal of finding new ways to treat young patients living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $552,209 |
| NIH project number | 5P01HD112217-03 |
| Project ID | NIH-11060884 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adolescents living with HIV, particularly those who are undergoing antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or those who are adults may not receive direct benefits from this research.
What this research studies
This research aims to explore the interactions between HIV and the immune systems of children, focusing on how HIV reservoirs are formed and maintained in young patients. By studying the role of CD8+ T cells, which are crucial for controlling HIV, the project seeks to identify unique aspects of the pediatric immune response that could lead to new treatment strategies. The research will involve developing specialized laboratory models that mimic the immune environment of children living with HIV, allowing for a deeper understanding of the disease's persistence in this population.
Why it matters
Potential benefit: If successful, this research could lead to innovative cure strategies specifically designed for children living with HIV.
How similar studies have gone: Previous research in adult populations has shown promising results in understanding HIV persistence, but this approach in pediatric models is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Mavigner, Maud — Emory University
- Study coordinator: Mavigner, Maud
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.