Understanding how HIV affects children's immune systems
Official title: Project-001
Funded at Emory University · NIH-11060881 · Data updated 2026-11-12
This study is looking at how the immune system works with HIV in children to understand why their bodies respond differently than adults, with the hope of finding new ways to help treat and possibly cure HIV in young patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $548,230 |
| NIH project number | 5P01HD112217-03 |
| Project ID | NIH-11060881 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children living with HIV, particularly those under the age of 20.
✕Less likely to help
Patients who are not living with HIV or those who are adults may not receive direct benefits from this research.
What this research studies
This research aims to explore the interactions between the immune system and HIV in children, focusing on how HIV reservoirs are formed and maintained in young patients. By studying the roles of specific immune factors like IL-10 and TGF-β, the project seeks to uncover why children living with HIV have different immune responses compared to adults. The research will involve analyzing immune cells from infants and children to identify potential new strategies for curing HIV in this population. The ultimate goal is to develop targeted treatments that can effectively address the unique challenges faced by children with HIV.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatment strategies that effectively reduce or eliminate HIV reservoirs in children, improving their long-term health outcomes.
How similar studies have gone: Previous research has shown promise in understanding immune responses in HIV, but this specific approach targeting the pediatric population is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Chahroudi, Ann M — Emory University
- Study coordinator: Chahroudi, Ann M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.