Understanding how HIV affects certain viruses linked to cancer in immune cells
(PQ4) Role of HIV-induced PLK1 Activation in Regulation of gamma-Herpesvirus Reservoirs in Lymphocytes
This study is looking at how HIV might help a certain protein, PLK1, affect some viruses that can cause cancer in people with weakened immune systems, like those living with HIV, to find new ways to treat or prevent these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11077857 on NIH RePORTER |
What this research studies
This research investigates the role of HIV in activating a specific protein, PLK1, which may influence the behavior of gamma-herpesviruses in immune cells. These viruses are known to be associated with various cancers, particularly in individuals with weakened immune systems, such as those living with HIV. The study aims to explore how PLK1 affects the latency and survival of these viruses, which could lead to better treatment strategies. By examining the interactions between HIV and these viruses, the research seeks to uncover potential therapeutic targets that could help manage or prevent virus-related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are at risk for gamma-herpesvirus-associated cancers.
Not a fit: Patients who are not HIV-positive or do not have a history of gamma-herpesvirus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of cancer in HIV-positive patients by targeting viral reservoirs.
How similar studies have performed: Previous research has shown promising results in targeting viral latency and cancer pathways, suggesting that this approach could be effective.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Santoso, Netty G — Ohio State University
- Study coordinator: Santoso, Netty G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.