Understanding how HIV affects blood vessel changes in the lungs
Official title: Role of HIV gp120 and Nef in Transcriptome Dysregulation and Pulmonary Vascular Remodeling
Funded at Texas Tech University Health Scis Center · NIH-10991665 · Data updated 2026-11-12
This study is looking at how HIV might lead to high blood pressure in the lungs and how certain genetic traits of the virus affect blood vessel health, so we can better understand this issue for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $613,996 |
| NIH project number | 5R01HL172709-02 |
| Project ID | NIH-10991665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are at risk of developing pulmonary hypertension.
✕Less likely to help
Patients who do not have HIV or those who do not exhibit risk factors for pulmonary hypertension may not benefit from this research.
What this research studies
This research investigates the mechanisms by which HIV contributes to the development of pulmonary hypertension (PH) in people living with HIV. It aims to explore how specific genetic variations in the HIV virus influence changes in blood vessel cells and the overall pulmonary vascular system. The study will utilize human vascular cells and specially designed mice to examine the effects of HIV on blood vessel function and structure, as well as the impact of antiretroviral therapy. By analyzing cellular responses and genetic changes, the research seeks to uncover critical insights into HIV-related vascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for pulmonary hypertension in individuals living with HIV.
How similar studies have gone: Previous research has shown associations between HIV and pulmonary hypertension, but this specific approach to understanding the underlying mechanisms is novel.
Where this research is happening
-
Texas Tech University Health Scis Center
Lubbock, United States Active
Researchers
- Principal investigator: Almodovar, Sharilyn — Texas Tech University Health Scis Center
- Study coordinator: Almodovar, Sharilyn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.