Understanding how HIV affects blood cell production
Official title: Decoding HIV-1 mediated Hematopathology
Funded at University of Maryland Baltimore · NIH-10778643 · Data updated 2026-11-12
This study is looking at how HIV affects the blood-making cells in your bone marrow, which could help explain why some people with HIV still have blood problems like anemia and low platelet counts, even when they're getting treatment.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 6, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $193,125 |
| NIH project number | 5R21AI174952-02 |
| Project ID | NIH-10778643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1 who are experiencing hematological abnormalities.
✕Less likely to help
Patients who are not infected with HIV or those without any hematological issues may not benefit from this research.
What this research studies
This research investigates the impact of HIV-1 infection on hematopoietic stem cells (HSCs) in the bone marrow, which are crucial for producing blood cells. It aims to uncover the mechanisms by which HIV disrupts normal blood cell development, leading to conditions like anemia and thrombocytopenia. By studying the relationship between HIV and HSCs, the research seeks to identify which blood cell progenitors are most affected by the virus. This could provide insights into the persistent blood disorders seen in HIV-infected patients, even with treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood disorders in HIV-infected patients, enhancing their overall health and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the effects of HIV on blood cell production, but this specific approach to studying HSCs is relatively novel.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Rathinam, Chozha Vendan — University of Maryland Baltimore
- Study coordinator: Rathinam, Chozha Vendan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.