Understanding how HIV affects blood cell production
Decoding HIV-1 mediated Hematopathology
['FUNDING_R21'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10778643
This study is looking at how HIV affects the blood-making cells in your bone marrow, which could help explain why some people with HIV still have blood problems like anemia and low platelet counts, even when they're getting treatment.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10778643 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of HIV-1 infection on hematopoietic stem cells (HSCs) in the bone marrow, which are crucial for producing blood cells. It aims to uncover the mechanisms by which HIV disrupts normal blood cell development, leading to conditions like anemia and thrombocytopenia. By studying the relationship between HIV and HSCs, the research seeks to identify which blood cell progenitors are most affected by the virus. This could provide insights into the persistent blood disorders seen in HIV-infected patients, even with treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who are experiencing hematological abnormalities.
Not a fit: Patients who are not infected with HIV or those without any hematological issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood disorders in HIV-infected patients, enhancing their overall health and quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the effects of HIV on blood cell production, but this specific approach to studying HSCs is relatively novel.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RATHINAM, CHOZHA VENDAN — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: RATHINAM, CHOZHA VENDAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Immunological Deficiency Syndromes, immune deficiency disorder, Immunologic Deficiency Syndromes, Infection