Understanding how HIV affects blood cell development at a single-cell level
Official title: Single-Cell Multi-Omic Analysis of Cell Differentiation in HIV Infection
Funded at University of Michigan at Ann Arbor · NIH-11007190 · Data updated 2026-11-12
This study is looking at how HIV affects blood cells over time by examining changes in their genes, which could help us find new ways to understand and track the infection.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $42,809 |
| NIH project number | 5F31AI177258-02 |
| Project ID | NIH-11007190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with HIV who are willing to provide blood samples for analysis.
✕Less likely to help
Patients who are not infected with HIV or those who are not willing to participate in blood sample collection may not benefit from this research.
What this research studies
This research investigates the complex interactions between gene expression and epigenomic changes in blood cells affected by HIV. By analyzing single-cell data, the study aims to uncover how HIV influences the differentiation of blood cells over time. The researchers will use advanced techniques to model these changes, providing insights into the timing and mechanisms of gene regulation during HIV infection. This could lead to the identification of new markers that indicate infection status.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and therapeutic strategies for individuals living with HIV.
How similar studies have gone: Previous research using single-cell multi-omic approaches has shown promise in understanding complex diseases, suggesting that this methodology could yield valuable insights into HIV infection.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Li, Chen — University of Michigan at Ann Arbor
- Study coordinator: Li, Chen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.