Understanding how HIV adapts and resists treatment
Official title: Mechanisms of HIV fitness and drug resistance inferred from high-resolution molecular dynamics and sequence co-variation models
Funded at Temple Univ of the Commonwealth · NIH-10894118 · Data updated 2026-11-12
This study is looking at how HIV changes and becomes resistant to medications, using advanced computer tools and lab experiments to better understand how these changes happen, which could help improve treatment for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $661,831 |
| NIH project number | 5R01AI178849-02 |
| Project ID | NIH-10894118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV who are undergoing antiretroviral therapy and may be experiencing treatment failure due to drug resistance.
✕Less likely to help
Patients who are newly diagnosed with HIV and have not yet started treatment may not benefit from this research.
What this research studies
This research investigates the mechanisms by which HIV evolves and develops resistance to antiretroviral drugs. By utilizing advanced computational tools and high-resolution molecular dynamics simulations, the team aims to forecast how HIV's genetic changes occur under the pressure of treatment. The study combines these simulations with experimental approaches to analyze specific HIV proteins, enhancing our understanding of viral behavior and treatment responses. This iterative process will help refine models that predict how HIV mutations can affect treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing HIV treatment and potentially prolong the effectiveness of existing therapies.
How similar studies have gone: Previous research has shown promise in using computational models to understand viral evolution, indicating that this approach could yield valuable insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Levy, Ronald — Temple Univ of the Commonwealth
- Study coordinator: Levy, Ronald
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.