Understanding how HIV-1 viruses are released from infected cells
Biochemistry of HIV-1 Budding
This study is looking at how HIV-1 viruses leave infected cells and what helps or hinders this process, with the goal of finding new ways to stop the virus from spreading, which could benefit people living with HIV.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11076275 on NIH RePORTER |
What this research studies
This research investigates the process by which HIV-1 viruses bud from infected cells, focusing on the role of host factors and the ESCRT pathway in this critical step of viral assembly. By employing a combination of structural, biochemical, imaging, and functional techniques, the research aims to uncover how viral membranes are formed and how the ESCRT machinery facilitates the release of the virus. Additionally, the study explores how certain mammals have evolved mechanisms to inhibit the release of HIV-1, potentially leading to broader protective strategies against similar viruses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV/AIDS who are interested in understanding the mechanisms of viral replication and potential new treatment avenues.
Not a fit: Patients who are not infected with HIV or those who have already developed resistance to current treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing the release of HIV-1, ultimately contributing to better treatments or vaccines for HIV/AIDS.
How similar studies have performed: Previous research has shown success in understanding viral assembly and release mechanisms, indicating that this approach has the potential for significant findings.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Sundquist, Wesley I. — University of Utah
- Study coordinator: Sundquist, Wesley I.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.