Understanding how HIV-1 viruses are released and mature in the body
Official title: Multiscale Simulation of HIV-1 Virion Release and Maturation
Funded at University of Chicago · NIH-10885201 · Data updated 2026-11-12
This study is looking at how the HIV-1 virus gets out of infected cells and grows up, using computer models to better understand these important steps, which could help in creating better treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $526,895 |
| NIH project number | 5R01AI178850-02 |
| Project ID | NIH-10885201 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1 who are interested in contributing to advancements in understanding the virus's lifecycle.
✕Less likely to help
Patients who are not infected with HIV-1 or those who are not engaged in HIV-related research may not benefit from this research.
What this research studies
This research investigates the complex processes involved in the lifecycle of HIV-1, particularly focusing on how the virus is released from infected cells and matures. Using advanced computer simulations, researchers will model the interactions of viral proteins and nucleic acids during these critical stages. The study aims to provide insights into the mechanisms of virion release and maturation, which are essential for developing effective treatments. By integrating computational models with experimental studies, the research seeks to enhance our understanding of HIV-1 biology.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing HIV-1 transmission and improving treatment options for infected individuals.
How similar studies have gone: Other research has shown success in using computational models to study viral processes, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Voth, Gregory a. — University of Chicago
- Study coordinator: Voth, Gregory a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.