Understanding how HIV-1 virus structures function inside cells
Characterizing functionally relevant HIV-1 structures by correlative light and cryo-electron microcopy (CLEM)
This study is looking at how the HIV virus works by using special imaging techniques to see how its protective shell breaks apart when it enters human cells, which could help us find new ways to treat HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-10765701 on NIH RePORTER |
What this research studies
This research investigates the HIV-1 capsid, which protects the viral genome and plays a crucial role in its entry into the host cell's nucleus. The project aims to develop advanced imaging techniques to visualize the disassembly of the capsid, a process essential for the virus to integrate its genetic material into the host's DNA. By using a combination of cryo-electron microscopy and light microscopy, researchers will analyze the dynamics of HIV-1 within cells, providing insights into how the virus operates at a molecular level. This could lead to a better understanding of HIV infection and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
Not a fit: Patients who are not infected with HIV or do not have risk factors for HIV are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating HIV infection.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques to study viral structures, indicating potential for success in this novel approach.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Francis, Ashwanth Christopher — Florida State University
- Study coordinator: Francis, Ashwanth Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.