Understanding how HIV-1 Vif protein affects immune response by degrading specific cellular proteins.
Official title: Cellular Determinants and Function Consequences of PP2A-B56 Degradation by HIV-1 Vif
Funded at Icahn School of Medicine at Mount Sinai · NIH-11076282 · Data updated 2026-11-12
This study is looking at how a part of the HIV virus helps it hide from our immune system by breaking down certain proteins, and it aims to find out how this affects the virus's ability to multiply in immune cells, which could help us discover better ways to treat HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 5, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $551,363 |
| NIH project number | 5R01AI167691-03 |
| Project ID | NIH-11076282 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are interested in understanding the mechanisms of their infection and potential new treatment options.
✕Less likely to help
Patients who are not infected with HIV or those who are not actively engaged in HIV treatment may not benefit from this research.
What this research studies
This research investigates how the HIV-1 Vif protein degrades certain proteins in the immune system, specifically focusing on the PP2A-B56 holoenzymes. By using advanced techniques like protein interaction technologies and CRISPR/Cas9 genetic screening, the study aims to uncover the cellular mechanisms that allow HIV-1 to evade the immune response. The research will also explore how these interactions impact HIV-1 replication in immune cells, which could lead to new insights into HIV treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for managing HIV infection and enhancing immune responses.
How similar studies have gone: Previous research has shown success in understanding viral mechanisms of immune evasion, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Johnson, Jeffrey R — Icahn School of Medicine at Mount Sinai
- Study coordinator: Johnson, Jeffrey R
Related research
Other NIH-funded projects on the same topics.
-
Improving Breast Cancer Guideline Adherence in Nigeria
Aimed at helping doctors in Nigeria follow international guideline-based breast cancer care to improve outcomes for women with breast cancer.
-
Genetically Validated PCOS Subtypes for Better Diagnosis and Risk Stratification
Aimed at women with polycystic ovary syndrome (PCOS), this project uses genetic data and patient characteristics to define distinct PCOS subtypes and improve how we diagnose and estimate risk.
-
Closed-loop control of interneuron timing to influence seizures and memory in epilepsy
A study tests a brain-quieting system that uses light to precisely time certain brain cells in epilepsy-prone mice to see if this can lessen seizures and improve memory.
-
Understanding why some brain regions and cells accumulate tau in Alzheimer’s and related diseases
Researchers are studying why certain brain areas and neuron types accumulate tau protein in Alzheimer’s and related conditions, and how this leads to brain changes and symptoms.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
Aging and brain injury connection: learning how late-life TBI relates to Alzheimer’s and related dementias
This grant looks at whether traumatic brain injuries in people 65 and older are linked to Alzheimer’s disease and related dementias, using a large, harmonized set of long-term aging studies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.