Understanding how HIV-1 Vif protein affects immune response by degrading specific cellular proteins.
Cellular Determinants and Function Consequences of PP2A-B56 Degradation by HIV-1 Vif
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11076282
This study is looking at how a part of the HIV virus helps it hide from our immune system by breaking down certain proteins, and it aims to find out how this affects the virus's ability to multiply in immune cells, which could help us discover better ways to treat HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11076282 on ClinicalTrials.gov |
What this research studies
This research investigates how the HIV-1 Vif protein degrades certain proteins in the immune system, specifically focusing on the PP2A-B56 holoenzymes. By using advanced techniques like protein interaction technologies and CRISPR/Cas9 genetic screening, the study aims to uncover the cellular mechanisms that allow HIV-1 to evade the immune response. The research will also explore how these interactions impact HIV-1 replication in immune cells, which could lead to new insights into HIV treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are interested in understanding the mechanisms of their infection and potential new treatment options.
Not a fit: Patients who are not infected with HIV or those who are not actively engaged in HIV treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for managing HIV infection and enhancing immune responses.
How similar studies have performed: Previous research has shown success in understanding viral mechanisms of immune evasion, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOHNSON, JEFFREY R — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: JOHNSON, JEFFREY R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome