Understanding how HIV-1 transcription is controlled
Official title: Control of HIV-1 Transcription by CPSF6 and PP2A
Funded at University of Utah · NIH-10900777 · Data updated 2026-11-12
This study is looking at how certain proteins help control the activity of HIV-1, with the goal of finding new ways to wake up hidden HIV in the body so that it can be treated better for people living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | August 7, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $192,500 |
| NIH project number | 5R21AI176884-02 |
| Project ID | NIH-10900777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who have a history of treatment and may have latent infections.
✕Less likely to help
Patients who are newly diagnosed with HIV or those who do not have a detectable viral load may not benefit from this research.
What this research studies
This research investigates the mechanisms that regulate HIV-1 transcription, particularly focusing on the role of specific proteins like CPSF6 and PP2A. By exploring how these proteins influence the activity of HIV-1, the research aims to identify new therapeutic strategies to target latent HIV reservoirs that evade the immune system. The approach involves studying the interactions between these proteins and the HIV-1 promoter to uncover potential methods for reactivating latent infections. This could lead to more effective treatments for individuals living with HIV.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that effectively target and eliminate latent HIV reservoirs, potentially curing HIV infection.
How similar studies have gone: Other research has shown promise in targeting HIV latency, but this specific approach focusing on CPSF6 and PP2A is relatively novel.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Planelles, Vicente — University of Utah
- Study coordinator: Planelles, Vicente
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.