Understanding how HIV-1 transcription is controlled
Control of HIV-1 Transcription by CPSF6 and PP2A
This study is looking at how certain proteins help control the activity of HIV-1, with the goal of finding new ways to wake up hidden HIV in the body so that it can be treated better for people living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10900777 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate HIV-1 transcription, particularly focusing on the role of specific proteins like CPSF6 and PP2A. By exploring how these proteins influence the activity of HIV-1, the research aims to identify new therapeutic strategies to target latent HIV reservoirs that evade the immune system. The approach involves studying the interactions between these proteins and the HIV-1 promoter to uncover potential methods for reactivating latent infections. This could lead to more effective treatments for individuals living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have a history of treatment and may have latent infections.
Not a fit: Patients who are newly diagnosed with HIV or those who do not have a detectable viral load may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that effectively target and eliminate latent HIV reservoirs, potentially curing HIV infection.
How similar studies have performed: Other research has shown promise in targeting HIV latency, but this specific approach focusing on CPSF6 and PP2A is relatively novel.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Planelles, Vicente — University of Utah
- Study coordinator: Planelles, Vicente
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.