Understanding how HIV-1 selects and packages its genetic material
Official title: Selective packaging and protection of HIV-1 genomic RNAs
Funded at Washington University · NIH-11112463 · Data updated 2026-11-12
This study is looking at how the HIV virus picks and packs its genetic material during assembly, which could help us understand how to create better treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | June 11, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $764,582 |
| NIH project number | 5R01AI179691-02 |
| Project ID | NIH-11112463 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals living with HIV-1 who are seeking new treatment options.
✕Less likely to help
Patients who are not infected with HIV-1 or those with other unrelated viral infections may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which HIV-1 selects and packages its genomic RNA during the virus assembly process. It focuses on the interactions between the HIV-1 protein Gag and the viral RNA, particularly how the RNA's composition influences its selection for packaging. By employing genetic and biochemical methods, the study aims to clarify the role of specific RNA sequences in this process, which is crucial for the virus's replication and infectivity. Patients may benefit from insights gained that could lead to improved antiviral therapies targeting these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for developing more effective treatments for HIV-1 infection.
How similar studies have gone: Previous research has shown success in understanding RNA-protein interactions in viral replication, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Kutluay, Sebla B. — Washington University
- Study coordinator: Kutluay, Sebla B.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.