Understanding how HIV-1 proteins move within infected cells
Official title: Function of HIV-1 Env cytoplasmic tail domain
Funded at Ohio State University · NIH-11190319 · Data updated 2026-11-12
This study is looking at how a part of the HIV virus moves around inside infected cells to find new ways to stop the virus from spreading, which could help develop better treatments for people living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $229,163 |
| NIH project number | 1R21AI191986-01 |
| Project ID | NIH-11190319 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1, particularly those who may benefit from new antiviral treatments.
✕Less likely to help
Patients who are not infected with HIV-1 or those who have already achieved viral suppression may not benefit from this research.
What this research studies
This research investigates the movement of the HIV-1 glycoprotein Env within infected cells to understand how it reaches sites where the virus buds and forms synapses. By studying the complex trafficking mechanisms of Env, the research aims to identify new targets for antiviral drug development, which is crucial in the ongoing fight against AIDS. The project utilizes a unique variant of the Env protein that has developed resistance to inhibitors, allowing researchers to explore its behavior in different cell types. This could lead to insights that enhance our ability to combat HIV-1 effectively.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies that more effectively target HIV-1.
How similar studies have gone: Previous research has shown promise in targeting viral proteins for antiviral development, indicating that this approach could yield significant results.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Root, Michael Jeffrey — Ohio State University
- Study coordinator: Root, Michael Jeffrey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.