Understanding how HIV-1 proteins mature in cells
Official title: HIV-1 Env gp160 maturation in the Golgi apparatus
Funded at University of Illinois at Chicago · NIH-11112311 · Data updated 2026-11-12
This study is looking at how a key part of the HIV virus gets ready to infect cells, with the hope of finding new ways to treat HIV and similar infections that could help patients like you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | May 10, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $399,750 |
| NIH project number | 5U01AI175008-03 |
| Project ID | NIH-11112311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
✕Less likely to help
Patients who are not infected with HIV or do not have a risk of exposure to HIV may not benefit from this research.
What this research studies
This research investigates the maturation process of the HIV-1 envelope glycoprotein in the Golgi apparatus, which is crucial for the virus's ability to infect cells. By examining how these proteins are processed and modified within the cell, the study aims to identify potential targets for therapeutic intervention. The approach involves detailed biochemical analysis and genetic techniques to understand the mechanisms that lead to successful viral replication. Patients may benefit from insights gained that could lead to new treatments for HIV and related viral infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating HIV infections.
How similar studies have gone: Previous research has shown success in targeting viral maturation processes, indicating potential for breakthroughs in treatment.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Zheng, Yong-Hui — University of Illinois at Chicago
- Study coordinator: Zheng, Yong-Hui
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.